Create a Nature Medicine / Science Translational Medicine style research paper figure, landscape 3:2 (1536×1024), soft literature-science palette, minimal and elegant.
Figure title: "Patient cohort and multimodal biomarker workflow".
Layout: a clean 4-panel academic figure labeled A–D with small bold panel letters.
A. CONSORT-style patient cohort flow diagram: "Screened n=1,248" → "Eligible n=612" → branch into "Training cohort n=428" and "External validation n=184". Include exclusion side boxes: "missing imaging n=81", "insufficient follow-up n=43", "quality-control fail n=32".
B. Multimodal sample-processing flow: icons for "CT imaging", "blood proteomics", "EHR timeline", "outcome labels" flowing into a pale-blue fusion box "feature harmonization".
C. Small Kaplan–Meier survival plot with two clean curves labeled "low-risk" and "high-risk", muted teal vs soft rose, x-axis "Months", y-axis "Event-free survival".
D. Compact table-style performance summary with three rows: "AUROC", "C-index", "Calibration slope" and two columns "Internal" / "External".
Style requirements: white background, light gray axes, thin lines, ample margins, muted teal, dusty blue, soft coral, pale sand, no neon, no dark background, Nature journal figure aesthetics, readable labels, precise arrows, subtle gridlines, no decorative clutter, no fake logos, no watermark.
中文翻譯
創作一張 Nature Medicine / Science Translational Medicine 風格的研究論文配圖，橫向 3:2（1536×1024），柔和的文獻科學配色，極簡而優雅。
圖標題：“患者隊列與多模態生物標誌物工作流”。
版式：一張乾淨的 4 分欄學術配圖，以 A–D 標註，分欄字母爲小號粗體。
A. CONSORT 式患者隊列流程圖：“篩選 n=1,248”→“合格 n=612”→分支爲“訓練隊列 n=428”與“外部驗證 n=184”。包含排除項側欄： “缺失影像 n=81”、“隨訪不足 n=43”、“質控不合格 n=32”。
B. 多模態樣本處理流程：圖標“CT 影像”、“血液蛋白質組學”、“EHR 時間軸”、“結局標籤”匯入一個淡藍色融合框“特徵統一化”。
C. 小型 Kaplan–Meier 生存曲線，兩條乾淨的曲線分別標註“低風險”與“高風險”，柔和青綠對比柔和玫瑰色，x 軸“月”，y 軸“無事件生存期”。
D. 緊湊的表格式性能彙總，三行：“AUROC”、“C 指數”、“校準斜率”，兩列“內部”／“外部”。
風格要求：白色背景、淺灰座標軸、細線條、充足留白、柔和青綠、灰藍、柔珊瑚、淡沙色，無霓虹，無深色背景，Nature 期刊配圖美學，標籤清晰可讀，箭頭精確，細微網格線，無裝飾性雜亂元素，無虛假 logo，無水印。
