Create a Nature Medicine / Science Translational Medicine style research paper figure, landscape 3:2 (1536×1024), soft literature-science palette, minimal and elegant.
Figure title: "Patient cohort and multimodal biomarker workflow".
Layout: a clean 4-panel academic figure labeled A–D with small bold panel letters.
A. CONSORT-style patient cohort flow diagram: "Screened n=1,248" → "Eligible n=612" → branch into "Training cohort n=428" and "External validation n=184". Include exclusion side boxes: "missing imaging n=81", "insufficient follow-up n=43", "quality-control fail n=32".
B. Multimodal sample-processing flow: icons for "CT imaging", "blood proteomics", "EHR timeline", "outcome labels" flowing into a pale-blue fusion box "feature harmonization".
C. Small Kaplan–Meier survival plot with two clean curves labeled "low-risk" and "high-risk", muted teal vs soft rose, x-axis "Months", y-axis "Event-free survival".
D. Compact table-style performance summary with three rows: "AUROC", "C-index", "Calibration slope" and two columns "Internal" / "External".
Style requirements: white background, light gray axes, thin lines, ample margins, muted teal, dusty blue, soft coral, pale sand, no neon, no dark background, Nature journal figure aesthetics, readable labels, precise arrows, subtle gridlines, no decorative clutter, no fake logos, no watermark.
中文译文
创作一张 Nature Medicine / Science Translational Medicine 风格的研究论文配图，横向 3:2（1536×1024），柔和的文献科学配色，极简而优雅。
图标题：“患者队列与多模态生物标志物工作流”。
版式：一张干净的 4 分栏学术配图，以 A–D 标注，分栏字母为小号粗体。
A. CONSORT 式患者队列流程图：“筛选 n=1,248”→“合格 n=612”→分支为“训练队列 n=428”与“外部验证 n=184”。包含排除项侧栏： “缺失影像 n=81”、“随访不足 n=43”、“质控不合格 n=32”。
B. 多模态样本处理流程：图标“CT 影像”、“血液蛋白质组学”、“EHR 时间轴”、“结局标签”汇入一个淡蓝色融合框“特征统一化”。
C. 小型 Kaplan–Meier 生存曲线，两条干净的曲线分别标注“低风险”与“高风险”，柔和青绿对比柔和玫瑰色，x 轴“月”，y 轴“无事件生存期”。
D. 紧凑的表格式性能汇总，三行：“AUROC”、“C 指数”、“校准斜率”，两列“内部”／“外部”。
风格要求：白色背景、浅灰坐标轴、细线条、充足留白、柔和青绿、灰蓝、柔珊瑚、淡沙色，无霓虹，无深色背景，Nature 期刊配图美学，标签清晰可读，箭头精确，细微网格线，无装饰性杂乱元素，无虚假 logo，无水印。
