Create a Nature Medicine style statistical results figure, landscape 3:2 (1536×1024), soft, restrained, publication-quality.
Figure title: "Therapeutic response across molecular subgroups".
Layout: 4-panel figure labeled A–D.
A. Grouped bar chart: response rate (%) for four subgroups "A", "B", "C", "D" across two treatments "standard" and "adaptive". Use muted navy and soft teal bars, thin error bars, numeric labels.
B. Forest plot of hazard ratios for subgroups with a vertical reference line at HR=1.0; rows "age <65", "age ≥65", "high inflammation", "low inflammation", "mutation-positive", "mutation-negative". Use small squares and confidence intervals.
C. Volcano-style biomarker association plot with pale gray background points and highlighted labeled markers "IL6", "CXCL10", "TP53", "MKI67".
D. Minimal mechanism schematic: adaptive therapy reduces inflammatory signaling and restores immune surveillance; use three clean nodes connected by arrows, no complex biology drawings.
Style requirements: literature-science aesthetic, white background, soft desaturated colors, thin gray axes, clear legends, compact labels, generous margins, Nature-style figure polish, no fake values that look too random, no decorative background, no watermark.
中文翻譯
創作一張 Nature Medicine 風格的統計結果圖，橫向 3:2（1536×1024），柔和、剋制、出版級品質。
圖標題：“分子亞組間的治療緩解情況”。
佈局：4 面板圖，以 A–D 標註。
A. 分組柱狀圖：四個亞組“A”“B”“C”“D”在“標準”與“適應性”兩種治療方案下的緩解率（%）。使用低飽和藏青色與柔和青綠色的柱條、細誤差線、數值標籤。
B. 亞組風險比的森林圖，在 HR=1.0 處有一條垂直參考線；各行標籤爲“年齡 <65”“年齡 ≥65”“高炎症”“低炎症”“突變陽性”“突變陰性”。使用小方塊與置信區間。
C. 火山圖風格的生物標誌物關聯圖，背景點爲淺灰色，並高亮標註的標記物“IL6”“CXCL10”“TP53”“MKI67”。
D. 極簡機制示意圖：適應性治療可減少炎症信號傳導並恢復免疫監視；使用三個乾淨的節點以箭頭相連，不要複雜的生物學繪圖。
風格要求：文獻科學美學，白色背景，柔和的低飽和度配色，細灰色座標軸，清晰的圖例，緊湊的標籤，充裕的留白，Nature 風格的配圖打磨，不要看起來過於隨機的假數值，不要裝飾性背景，無水印。
